FRMD8

Across TCGA cell cohorts, FRMD8 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,984 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FRMD8-associated GO terms across cancer lineages are Vacuole organization, Negative regulation of calcium ion export across plasma membrane, and mRNA alternative polyadenylation. Each is linked with FRMD8 in more than 12 cancer types. Because this analysis shows association rather than direction, both FRMD8-to-partner and partner-to-FRMD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Vacuole organization grouped by FRMD8-low versus FRMD8-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FRMD8→partner) and Y-score (partner→FRMD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Vacuole organization →	+0.066	+0.969	<.001	<.001	3	13
BLOOD_Lymphoma	Negative regulation of calcium ion export across plasma membrane →	+0.063	+0.974	<.001	<.001	3	11
LARGE_INTESTINE	mRNA alternative polyadenylation →	+0.104	+1.110	<.001	<.001	3	10
SKIN	Pre-mRNA catabolic process →	+0.127	+0.989	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Negative regulation of autophagy →	+0.082	+1.060	<.001	.001	3	10
SOFT_TISSUE	Transcription pausing by RNA polymerase II →	+0.099	+0.939	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,984 associations by consensus.

Vacuole organization by FRMD8 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →