FRMD7

Across TCGA patient cohorts, FRMD7 mutation is significantly associated with the RNA expression of many other genes, with 3,206 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FRMD7-associated genes across cancer lineages are OR4C9P, CPSF4, and STOML2. Each is linked with FRMD7 in more than 2 cancer types. Because this analysis shows association rather than direction, both FRMD7-to-partner and partner-to-FRMD7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4C9P grouped by FRMD7-low versus FRMD7-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRMD7→partner) and Y-score (partner→FRMD7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	OR4C9P →	+0.011	+4.333	<.001	.005	3	3
UCEC	CPSF4 →	+0.269	+2.024	.008	.001	3	3
UCEC	STOML2 →	+0.329	+1.692	.005	.003	3	3
UCEC	CIAO2B →	+0.415	+2.168	<.001	<.001	3	3
SKCM	KIF22 →	+0.396	+4.149	<.001	<.001	3	3
SKCM	BRF2 →	+0.388	+3.188	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,206 associations by consensus.

OR4C9P by FRMD7 expression — LUAD

Explore this box plot interactively →