FRMD7

Across TCGA patient cohorts, FRMD7 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FRMD7-associated genes across cancer lineages are Notch1, ATM, and Cyclin-B1. Each is linked with FRMD7 in more than 2 cancer types. Because this analysis shows association rather than direction, both FRMD7-to-partner and partner-to-FRMD7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by FRMD7-low versus FRMD7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRMD7→partner) and Y-score (partner→FRMD7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.120	+1.598	.006	.019	3	3
UCEC	ATM →	-0.368	-1.502	.009	.027	3	3
UCEC	Cyclin-B1 →	+0.520	+1.836	.003	.001	3	3
UCEC	mTOR_pS2448 →	-0.094	-1.658	.045	.021	3	2
UCEC	TIGAR →	+0.119	+1.611	.013	.003	3	2
UCEC	Caspase-8 →	-0.244	-2.476	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

Notch1 by FRMD7 expression — UCEC

Explore this box plot interactively →