FRMD7

Across TCGA cell cohorts, FRMD7 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. CNS shows the largest number of these associations.

The most reproducible FRMD7-associated genes across cancer lineages are SLC6A17, STATH, and CER1. Each is linked with FRMD7 in more than 1 cancer types. Because this analysis shows association rather than direction, both FRMD7-to-partner and partner-to-FRMD7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC6A17 grouped by FRMD7-low versus FRMD7-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRMD7→partner) and Y-score (partner→FRMD7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC6A17 →	+0.205	+4.037	<.001	.004	3	1
CNS	STATH →	+0.354	+4.643	<.001	.003	3	1
CNS	CER1 →	+0.248	+4.472	<.001	.004	3	1
CNS	PGLYRP2 →	+0.354	+4.169	<.001	.008	3	1
CNS	PYDC1 →	+0.156	+4.754	<.001	.005	3	1
CNS	SPDYC →	+0.317	+4.169	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

SLC6A17 by FRMD7 expression — BLOOD_Leukemia

Explore this box plot interactively →