FRMD6

Across TCGA patient cohorts, FRMD6 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FRMD6-associated genes across cancer lineages are Notch1, Caspase-7-cleavedD198, and EGFR_pY1068. Each is linked with FRMD6 in more than 1 cancer types. Because this analysis shows association rather than direction, both FRMD6-to-partner and partner-to-FRMD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by FRMD6-low versus FRMD6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRMD6→partner) and Y-score (partner→FRMD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.154	+1.775	<.001	.007	3	2
UCEC	Caspase-7-cleavedD198 →	+0.754	+2.502	<.001	.001	3	2
UCEC	EGFR_pY1068 →	-0.287	-2.058	<.001	<.001	3	1
UCEC	EGFR →	-0.178	-3.558	<.001	.002	3	1
UCEC	eIF4E →	+0.184	+3.713	.006	<.001	3	1
UCEC	ERK2 →	+0.165	+1.765	.007	.013	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Notch1 by FRMD6 expression — UCEC

Explore this box plot interactively →