FRMD6

Across TCGA cell cohorts, FRMD6 mutation is significantly associated with the RNA expression of many other genes, with 477 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FRMD6-associated genes across cancer lineages are SIGLEC5, TEX33, and PLET1. Each is linked with FRMD6 in more than 1 cancer types. Because this analysis shows association rather than direction, both FRMD6-to-partner and partner-to-FRMD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIGLEC5 grouped by FRMD6-low versus FRMD6-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRMD6→partner) and Y-score (partner→FRMD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SIGLEC5 →	+0.248	+3.481	<.001	.004	3	1
LUNG_NSCLC_LUAD	TEX33 →	+0.018	+4.266	<.001	.004	3	1
LUNG_NSCLC_LUAD	PLET1 →	+0.044	+3.584	.006	.007	3	1
LUNG_SCLC	BPIFB6 →	+0.012	+5.029	.001	.006	3	1
LUNG_SCLC	OR2T4 →	+0.083	+5.643	<.001	.002	3	1
LARGE_INTESTINE	GCAT →	+1.359	+3.169	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 477 associations by consensus.

SIGLEC5 by FRMD6 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →