FRMD6-AS2

Across TCGA pan-cancer cohorts, FRMD6-AS2 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of FRMD6-AS2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where FRMD6-AS2 RNA is repressed in tumor relative to normal tissue. In most cancer types FRMD6-AS2 is over-expressed in tumor, although a few such as COAD and BLCA show the opposite, repressed pattern.

COAD, BLCA, and UCEC are the cancer types where FRMD6-AS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FRMD6-AS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	−0.682	<.001	11	view →
BLCA	All	III,IV	−1.332	<.001	10	view →
UCEC	All	All	−3.994	<.001	8	view →
STAD	All	All	−0.632	<.001	8	view →
BRCA	Female	All	−0.091	<.001	6	view →
READ	All	All	−0.922	.002	3	view →
PRAD	All	All	−0.835	<.001	2	view →
HNSC	All	IV	+0.070	.019	2	view →
LUAD	All	III,IV	−0.138	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

FRMD6-AS2–COAD

Open the COAD breakdown →