FRMD5

Across TCGA patient cohorts, FRMD5 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FRMD5-associated genes across cancer lineages are Caspase-7-cleavedD198, Bim, and 14-3-3_beta. Each is linked with FRMD5 in more than 1 cancer types. Because this analysis shows association rather than direction, both FRMD5-to-partner and partner-to-FRMD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by FRMD5-low versus FRMD5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRMD5→partner) and Y-score (partner→FRMD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.711	+3.019	<.001	<.001	3	2
SKCM	Bim →	-0.288	-3.000	.037	.035	3	2
UCEC	14-3-3_beta →	-0.079	-1.209	.015	.035	3	1
UCEC	EGFR_pY1173 →	-0.068	-1.886	.009	.015	3	1
UCEC	eIF4E →	+0.181	+3.598	.008	.001	3	1
UCEC	Heregulin →	-0.089	-1.584	.026	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Caspase-7-cleavedD198 by FRMD5 expression — UCEC

Explore this box plot interactively →