FRMD5

Across TCGA cell cohorts, FRMD5 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FRMD5-associated genes across cancer lineages are AVP, KRTAP4-4, and IFNA8. Each is linked with FRMD5 in more than 1 cancer types. Because this analysis shows association rather than direction, both FRMD5-to-partner and partner-to-FRMD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by FRMD5-low versus FRMD5-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRMD5→partner) and Y-score (partner→FRMD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	AVP →	+0.031	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	KRTAP4-4 →	+0.032	+5.643	<.001	.002	3	1
SKIN	IFNA8 →	+0.021	+4.977	.001	.007	3	1
SKIN	OR2J2 →	+0.013	+4.977	<.001	.007	3	1
SKIN	KRTAP10-1 →	+0.019	+4.977	<.001	.007	3	1
SKIN	OR8B4 →	+0.035	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

AVP by FRMD5 expression — BLOOD_Lymphoma

Explore this box plot interactively →