FRMD4A

Across TCGA pan-cancer cohorts, FRMD4A mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated FRMD4A data layer compared with 25 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher FRMD4A mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated FRMD4A expression acts as an unfavorable survival marker, although some lineages such as UCEC and CCRCC show a favorable association.

UCEC and CCRCC are the cancer types where FRMD4A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	II,III,IV	1.000	0.578	.011	4	view →
CCRCC	OS	Quartile	II,III,IV	0.810	0.560	.046	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

FRMD4A–UCEC (OS)

Open the UCEC breakdown →