FRMD4A

Across TCGA patient cohorts, FRMD4A mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FRMD4A-associated genes across cancer lineages are EGFR_pY1068, 4E-BP1, and 14-3-3_beta. Each is linked with FRMD4A in more than 2 cancer types. Because this analysis shows association rather than direction, both FRMD4A-to-partner and partner-to-FRMD4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by FRMD4A-low versus FRMD4A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRMD4A→partner) and Y-score (partner→FRMD4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.258	-2.237	<.001	<.001	3	3
UCEC	4E-BP1 →	+0.298	+2.584	<.001	<.001	3	3
UCEC	14-3-3_beta →	-0.080	-1.651	.005	.019	3	2
UCEC	eEF2 →	+0.241	+1.054	.018	.029	3	2
COAD	eIF4E →	+0.176	+2.820	.014	.035	3	2
UCEC	ERK2 →	+0.211	+2.662	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

EGFR_pY1068 by FRMD4A expression — UCEC

Explore this box plot interactively →