FRMD4A

Across TCGA cell cohorts, FRMD4A RNA expression is significantly associated with the go_rna of many other GO terms, with 3,862 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible FRMD4A-associated GO terms across cancer lineages are Positive regulation of cell-substrate junction organization, PML body organization, and Regulation of inflammatory response to antigenic stimulus. Each is linked with FRMD4A in more than 12 cancer types. Because this analysis shows association rather than direction, both FRMD4A-to-partner and partner-to-FRMD4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of cell-substrate junction organization grouped by FRMD4A-low versus FRMD4A-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FRMD4A→partner) and Y-score (partner→FRMD4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Positive regulation of cell-substrate junction organization →	+0.178	+2.663	<.001	<.001	3	13
OVARY	PML body organization →	+0.199	+1.882	<.001	<.001	3	11
OVARY	Regulation of inflammatory response to antigenic stimulus →	+0.090	+1.848	<.001	<.001	3	10
LARGE_INTESTINE	Regulation of hippo signaling →	+0.071	+1.324	<.001	<.001	3	10
SKIN	Cellular response to transforming growth factor beta stimulus →	+0.071	+1.739	.001	.002	3	10
LUNG_NSCLC_LUSC	Golgi to plasma membrane protein transport →	+0.147	+2.425	.001	.008	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,862 associations by consensus.

Positive regulation of cell-substrate junction organization by FRMD4A expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →