FRMD4A

Across TCGA cell cohorts, FRMD4A mutation is significantly associated with the RNA expression of many other genes, with 633 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FRMD4A-associated genes across cancer lineages are MSGN1, KLKB1, and PTTG2. Each is linked with FRMD4A in more than 1 cancer types. Because this analysis shows association rather than direction, both FRMD4A-to-partner and partner-to-FRMD4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSGN1 grouped by FRMD4A-low versus FRMD4A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRMD4A→partner) and Y-score (partner→FRMD4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MSGN1 →	+0.049	+2.538	.002	.005	3	2
LARGE_INTESTINE	KLKB1 →	+0.416	+3.237	<.001	.003	3	2
LARGE_INTESTINE	PTTG2 →	+0.063	+3.719	.003	.001	3	2
BLOOD_Leukemia	AADACL2 →	+0.006	+2.922	.006	.009	3	2
SOFT_TISSUE	C8orf74 →	+0.029	+5.369	<.001	.004	3	1
SOFT_TISSUE	OR10V1 →	+0.042	+5.369	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 633 associations by consensus.

MSGN1 by FRMD4A expression — LARGE_INTESTINE

Explore this box plot interactively →