FRMD3

Across TCGA patient cohorts, FRMD3 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FRMD3-associated genes across cancer lineages are STAT3_pY705, ACC_pS79, and ACC1. Each is linked with FRMD3 in more than 2 cancer types. Because this analysis shows association rather than direction, both FRMD3-to-partner and partner-to-FRMD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by FRMD3-low versus FRMD3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRMD3→partner) and Y-score (partner→FRMD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	STAT3_pY705 →	-0.392	-3.136	.003	.018	3	3
UCEC	ACC_pS79 →	+0.347	+1.652	.002	.006	3	2
UCEC	ACC1 →	+0.308	+1.652	.010	.006	3	2
UCEC	Annexin_VII →	-0.135	-2.312	.003	.005	3	2
UCEC	ASNS →	+0.456	+1.906	<.001	.014	3	2
UCEC	Caspase-8 →	-0.214	-1.938	.009	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

STAT3_pY705 by FRMD3 expression — SKCM

Explore this box plot interactively →