FRMD3

Across TCGA cell cohorts, FRMD3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,178 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible FRMD3-associated GO terms across cancer lineages are Negative regulation of endoplasmic reticulum unfolded protein response, Renal water transport, and Cytoplasmic translation. Each is linked with FRMD3 in more than 7 cancer types. Because this analysis shows association rather than direction, both FRMD3-to-partner and partner-to-FRMD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of endoplasmic reticulum unfolded protein response grouped by FRMD3-low versus FRMD3-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FRMD3→partner) and Y-score (partner→FRMD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Negative regulation of endoplasmic reticulum unfolded protein response →	+0.077	+1.355	.002	.001	2	8
LUNG_SCLC	Renal water transport →	-0.786	-1.573	.009	.001	3	6
BREAST	Cytoplasmic translation →	+0.077	+0.902	<.001	<.001	3	6
BREAST	Negative regulation of syncytium formation by plasma membrane fusion →	+0.094	+0.979	<.001	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	Golgi to endosome transport →	+0.068	+0.950	<.001	.001	3	6
SOFT_TISSUE	Alternative mRNA splicing, via spliceosome →	+0.076	+1.069	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,178 associations by consensus.

Negative regulation of endoplasmic reticulum unfolded protein response by FRMD3 expression — STOMACH

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