FRMD3

Across TCGA cell cohorts, FRMD3 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible FRMD3-associated genes across cancer lineages are PRAMEF17, ANKRD63, and DYTN. Each is linked with FRMD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both FRMD3-to-partner and partner-to-FRMD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF17 grouped by FRMD3-low versus FRMD3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRMD3→partner) and Y-score (partner→FRMD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PRAMEF17 →	+0.008	+4.022	<.001	.006	3	1
SKIN	ANKRD63 →	+0.071	+3.684	<.001	.009	3	1
SKIN	DYTN →	+0.071	+3.632	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

PRAMEF17 by FRMD3 expression — SKIN

Explore this box plot interactively →