FRMD1

Across TCGA patient cohorts, FRMD1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,939 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible FRMD1-associated GO terms across cancer lineages are Negative regulation of post-translational protein modification, Tubulin complex assembly, and TORC1 signaling. Each is linked with FRMD1 in more than 11 cancer types. Because this analysis shows association rather than direction, both FRMD1-to-partner and partner-to-FRMD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of post-translational protein modification grouped by FRMD1-low versus FRMD1-high in LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FRMD1→partner) and Y-score (partner→FRMD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	Negative regulation of post-translational protein modification →	+0.020	+0.196	<.001	<.001	3	12
THYM	Tubulin complex assembly →	+0.047	+1.231	.001	.004	3	11
OV	TORC1 signaling →	+0.033	+0.311	<.001	<.001	3	11
HNSC	Establishment of protein localization to membrane →	+0.021	+0.256	<.001	<.001	3	11
LUSC	Regulation of membrane permeability →	+0.037	+0.257	<.001	<.001	3	10
HNSC	Positive regulation of membrane permeability →	+0.030	+0.227	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,939 associations by consensus.

Negative regulation of post-translational protein modification by FRMD1 expression — LUSC

Explore this box plot interactively →