FRK

Across TCGA pan-cancer cohorts, FRK mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FRK data layer compared with 26 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher FRK mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated FRK expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

CCRCC, HNSC, and LUAD are the cancer types where FRK mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	II,III,IV	1.000	0.829	.009	12	view →
HNSC	DFS	Quartile	III,IV	0.871	1.000	.016	10	view →
LUAD	DFS	Median	II,III,IV	0.374	0.644	.044	2	view →
UCEC	DFS	Median	All	0.794	0.925	.034	2	view →
PDAC	OS	Quartile	III,IV	0.531	0.823	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FRK–CCRCC (OS)

Open the CCRCC breakdown →