FRK

Across TCGA patient cohorts, FRK mutation is significantly associated with the RNA expression of many other genes, with 3,361 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FRK-associated genes across cancer lineages are RN7SL386P, RNA5SP412, and EME1. Each is linked with FRK in more than 2 cancer types. Because this analysis shows association rather than direction, both FRK-to-partner and partner-to-FRK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL386P grouped by FRK-low versus FRK-high in OV.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRK→partner) and Y-score (partner→FRK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RN7SL386P →	+0.262	+4.787	<.001	.006	3	3
UCEC	RNA5SP412 →	+0.511	+1.967	<.001	<.001	3	3
UCEC	EME1 →	+0.451	+1.726	.004	.002	3	3
COAD	TRDV3 →	+0.878	+3.178	<.001	.003	3	3
UCEC	SPAG5 →	+0.540	+2.000	.002	.001	3	3
UCEC	FARSB →	+0.337	+2.917	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,361 associations by consensus.

RN7SL386P by FRK expression — OV

Explore this box plot interactively →