FRK

Across TCGA patient cohorts, FRK mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FRK-associated genes across cancer lineages are Annexin-1, eIF4G, and p62 Lck ligand. Each is linked with FRK in more than 2 cancer types. Because this analysis shows association rather than direction, both FRK-to-partner and partner-to-FRK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by FRK-low versus FRK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRK→partner) and Y-score (partner→FRK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.534	+2.720	.003	.003	3	3
UCEC	eIF4G →	+0.262	+2.584	.014	.010	3	2
UCEC	p62 Lck ligand →	+0.406	+2.938	<.001	<.001	3	2
UCEC	PCNA →	+0.239	+2.070	.001	.001	3	2
UCEC	Caspase-8 →	-0.260	-4.060	.002	<.001	3	2
UCEC	Cyclin-B1 →	+0.546	+1.700	.005	.042	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

Annexin-1 by FRK expression — UCEC

Explore this box plot interactively →