FRG2KP

Across TCGA patient cohorts, FRG2KP mutation is significantly associated with the RNA expression of many other genes, with 555 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FRG2KP-associated genes across cancer lineages are RNU6-206P, PSPN, and METTL16. Each is linked with FRG2KP in more than 1 cancer types. Because this analysis shows association rather than direction, both FRG2KP-to-partner and partner-to-FRG2KP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-206P grouped by FRG2KP-low versus FRG2KP-high in GBM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRG2KP→partner) and Y-score (partner→FRG2KP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RNU6-206P →	+0.495	+5.937	<.001	<.001	3	2
UCEC	PSPN →	+0.421	+2.823	<.001	.001	3	2
UCEC	METTL16 →	+0.678	+4.042	<.001	<.001	3	2
UCEC	DIAPH1 →	+0.443	+2.354	.005	.003	3	2
UCEC	NDUFAF1 →	+0.395	+2.595	.006	<.001	3	2
BLCA	RNU4-15P →	+0.373	+6.732	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 555 associations by consensus.

RNU6-206P by FRG2KP expression — GBM

Explore this box plot interactively →