FRG2KP

Across TCGA patient cohorts, FRG2KP mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FRG2KP-associated genes across cancer lineages are eEF2, ERK2, and IGFBP2. Each is linked with FRG2KP in more than 1 cancer types. Because this analysis shows association rather than direction, both FRG2KP-to-partner and partner-to-FRG2KP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by FRG2KP-low versus FRG2KP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRG2KP→partner) and Y-score (partner→FRG2KP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.541	+2.906	<.001	.001	3	2
UCEC	ERK2 →	+0.215	+1.700	.008	.044	3	1
UCEC	IGFBP2 →	-0.652	-3.321	.018	.010	3	1
UCEC	ACVRL1 →	-0.146	-3.565	.011	.002	3	1
UCEC	JNK_pT183_Y185 →	-0.143	-1.687	.046	.044	3	1
UCEC	JNK2 →	+0.313	+2.222	<.001	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

eEF2 by FRG2KP expression — UCEC

Explore this box plot interactively →