Across TCGA patient cohorts, FRG2 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FRG2-associated genes across cancer lineages are A-Raf_pS299, GATA3, and GSK3-a-b. Each is linked with FRG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FRG2-to-partner and partner-to-FRG2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRG2→partner) and Y-score (partner→FRG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.103	-2.222	.041	.011	3	1
UCEC	GATA3 →	+0.163	+2.235	.041	.006	3	1
UCEC	GSK3-a-b →	-0.122	-3.169	.034	.019	3	1
UCEC	Lck →	+0.271	+3.321	.001	.010	3	1
UCEC	MEK1 →	+0.337	+3.321	.029	.010	3	1
UCEC	MSH2 →	-0.242	-1.700	.013	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Exploration

FRG2 survival (RNA) · tumor vs normal (RNA) · all FRG2 data types