FRG1

Across TCGA cell cohorts, FRG1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,365 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FRG1-associated GO terms across cancer lineages are U1 snRNA 3'-end processing, U5 snRNA 3'-end processing, and DNA replication, synthesis of primer. Each is linked with FRG1 in more than 11 cancer types. Because this analysis shows association rather than direction, both FRG1-to-partner and partner-to-FRG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, U1 snRNA 3'-end processing grouped by FRG1-low versus FRG1-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FRG1→partner) and Y-score (partner→FRG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	U1 snRNA 3'-end processing →	+0.140	+0.832	<.001	<.001	3	12
STOMACH	U5 snRNA 3'-end processing →	+0.140	+0.832	<.001	<.001	3	12
LUNG_SCLC	DNA replication, synthesis of primer →	+0.139	+0.735	.001	.002	3	12
STOMACH	Regulation of protein ADP-ribosylation →	+0.149	+0.812	.002	.006	2	11
URINARY_TRACT	Monoubiquitinated protein deubiquitination →	+0.125	+0.889	.001	.001	3	10
KIDNEY	DAMP biosynthetic process →	+0.155	+0.554	<.001	.006	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,365 associations by consensus.

U1 snRNA 3'-end processing by FRG1 expression — STOMACH

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