FRG1

Across TCGA cell cohorts, FRG1 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FRG1-associated genes across cancer lineages are OR11A1, OR5V1, and TBC1D21. Each is linked with FRG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FRG1-to-partner and partner-to-FRG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR11A1 grouped by FRG1-low versus FRG1-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRG1→partner) and Y-score (partner→FRG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	OR11A1 →	+0.016	+5.285	<.001	.003	3	1
STOMACH	OR5V1 →	+0.056	+5.285	<.001	.003	3	1
LARGE_INTESTINE	TBC1D21 →	+0.015	+5.022	<.001	.002	3	1
LARGE_INTESTINE	GSG1L2 →	+0.020	+5.022	<.001	.002	3	1
LARGE_INTESTINE	PYDC2 →	+0.108	+4.415	<.001	.007	3	1
LARGE_INTESTINE	CD300H →	+0.039	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

OR11A1 by FRG1 expression — STOMACH

Explore this box plot interactively →