Across TCGA patient cohorts, FREM3 RNA expression is significantly associated with the protein abundance of many other proteins, with 7,768 significant associations in total. GBM shows the largest number of these associations.

The most reproducible FREM3-associated proteins across cancer lineages are MTMR12, PDCD6, and RPS3A. Each is linked with FREM3 in more than 3 cancer types. Because this analysis shows association rather than direction, both FREM3-to-partner and partner-to-FREM3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (FREM3→partner) and Y-score (partner→FREM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MTMR12 →	+0.268	+0.386	<.001	.001	2	4
LSCC	PDCD6 →	+0.337	+0.432	<.001	<.001	3	3
GBM	RPS3A →	-0.193	-0.712	<.001	.008	3	3
LSCC	C5orf51 →	+0.245	+0.288	<.001	<.001	3	3
UCEC	CERT1 →	-0.344	-0.485	.001	<.001	3	3
GBM	LARP4_S722 →	-0.512	-1.134	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,768 associations by consensus.

Exploration

FREM3 survival (RNA) · tumor vs normal (RNA) · all FREM3 data types