Across TCGA patient cohorts, FREM3 protein abundance is significantly associated with the RNA expression of many other genes, with 374 significant associations in total. GBM shows the largest number of these associations.

The most reproducible FREM3-associated genes across cancer lineages are MXRA5, RHOXF1, and RENBP. Each is linked with FREM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both FREM3-to-partner and partner-to-FREM3 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FREM3→partner) and Y-score (partner→FREM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MXRA5 →	-1.902	-1.938	<.001	.002	3	1
GBM	RHOXF1 →	+0.673	+2.961	.001	<.001	3	1
GBM	RENBP →	-1.483	-2.608	<.001	.001	3	1
GBM	PCSK1N →	+1.623	+1.701	.007	.009	3	1
GBM	DHODH →	+0.341	+1.883	.001	.003	3	1
GBM	DYRK1B →	+0.950	+2.511	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 374 associations by consensus.

Exploration

FREM3 survival (RNA) · tumor vs normal (RNA) · all FREM3 data types