Across TCGA cell cohorts, FREM3 RNA expression is significantly associated with the go_rna of many other GO terms, with 199 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FREM3-associated GO terms across cancer lineages are Negative regulation of calcium ion export across plasma membrane, Negative regulation of canonical NF-kappaB signal transduction, and Internal protein amino acid acetylation. Each is linked with FREM3 in more than 2 cancer types. Because this analysis shows association rather than direction, both FREM3-to-partner and partner-to-FREM3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FREM3→partner) and Y-score (partner→FREM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Negative regulation of calcium ion export across plasma membrane →	+0.040	+0.078	.006	.004	3	3
BLOOD_Leukemia	Negative regulation of canonical NF-kappaB signal transduction →	+0.020	+0.040	.009	.008	3	3
BLOOD_Leukemia	Internal protein amino acid acetylation →	+0.069	+0.052	<.001	.008	3	3
BLOOD_Lymphoma	Positive regulation of autophagy →	+0.030	+0.035	.002	.006	3	2
BLOOD_Lymphoma	Positive regulation of sterol biosynthetic process →	+0.099	+0.034	<.001	.007	3	2
BLOOD_Lymphoma	Endosomal transport →	+0.034	+0.034	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 199 associations by consensus.

Exploration

FREM3 survival (RNA) · tumor vs normal (RNA) · all FREM3 data types