Across TCGA cell cohorts, FREM3 mutation is significantly associated with the RNA expression of many other genes, with 548 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FREM3-associated genes across cancer lineages are EIF3E, FRG1, and SLIRP. Each is linked with FREM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both FREM3-to-partner and partner-to-FREM3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FREM3→partner) and Y-score (partner→FREM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	EIF3E →	+0.796	+3.584	<.001	<.001	3	2
LARGE_INTESTINE	FRG1 →	+0.400	+3.459	.003	.001	3	2
LARGE_INTESTINE	SLIRP →	+0.502	+3.169	.005	.006	3	2
LARGE_INTESTINE	RSL24D1 →	+0.599	+3.743	<.001	<.001	3	2
LARGE_INTESTINE	FRA10AC1 →	+0.595	+2.628	<.001	.002	3	2
SKIN	PDCL2 →	+0.245	+3.345	.003	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 548 associations by consensus.

Exploration

FREM3 survival (RNA) · tumor vs normal (RNA) · all FREM3 data types