FREM2

Across TCGA pan-cancer cohorts, FREM2 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated FREM2 data layer compared with 24 for mass-spec protein and 12 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher FREM2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated FREM2 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC and HNSC are the cancer types where FREM2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	0.909	0.563	.001	29	view →
HNSC	DFS	Quartile	III,IV	0.812	0.437	.002	8	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

FREM2–CCRCC (DFS)

Open the CCRCC breakdown →