FREM2

Across TCGA patient cohorts, FREM2 mutation is significantly associated with the RNA expression of many other genes, with 7,230 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FREM2-associated genes across cancer lineages are DEPDC1, C7, and NUDC. Each is linked with FREM2 in more than 5 cancer types. Because this analysis shows association rather than direction, both FREM2-to-partner and partner-to-FREM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEPDC1 grouped by FREM2-low versus FREM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FREM2→partner) and Y-score (partner→FREM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DEPDC1 →	+0.352	+1.010	.009	.003	3	6
LUAD	C7 →	-1.446	-3.087	.001	<.001	3	5
COAD	NUDC →	+0.341	+2.382	<.001	<.001	3	5
COAD	CENPU →	+0.552	+2.529	<.001	<.001	3	5
UCEC	TSPAN7 →	-1.051	-1.516	<.001	<.001	3	5
UCEC	CHAF1B →	+0.545	+1.306	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,230 associations by consensus.

DEPDC1 by FREM2 expression — UCEC

Explore this box plot interactively →