FREM2

Across TCGA patient cohorts, FREM2 mutation is significantly associated with the total protein of many other genes, with 94 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FREM2-associated genes across cancer lineages are FASN, TFRC, and ASNS. Each is linked with FREM2 in more than 4 cancer types. Because this analysis shows association rather than direction, both FREM2-to-partner and partner-to-FREM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by FREM2-low versus FREM2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FREM2→partner) and Y-score (partner→FREM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FASN →	+0.265	+1.874	.015	.047	3	5
COAD	TFRC →	+0.370	+1.841	.013	.012	3	5
COAD	ASNS →	+0.534	+2.178	<.001	<.001	3	4
LUAD	Bak →	+0.139	+3.321	.004	.009	3	4
COAD	PDCD4 →	-0.379	-1.884	.001	<.001	3	4
COAD	PKC-b-II_pS660 →	-0.259	-1.736	.009	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 94 associations by consensus.

FASN by FREM2 expression — COAD

Explore this box plot interactively →