FREM2

Across TCGA cell cohorts, FREM2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,778 significant associations in total. BONE shows the largest number of these associations.

The most reproducible FREM2-associated GO terms across cancer lineages are Glial cell fate commitment, Oncostatin-M-mediated signaling pathway, and Cytolysis in another organism. Each is linked with FREM2 in more than 9 cancer types. Because this analysis shows association rather than direction, both FREM2-to-partner and partner-to-FREM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Glial cell fate commitment grouped by FREM2-low versus FREM2-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FREM2→partner) and Y-score (partner→FREM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Glial cell fate commitment →	+2.245	+1.854	<.001	<.001	3	9
BONE	Oncostatin-M-mediated signaling pathway →	-0.261	-1.063	<.001	<.001	3	9
BONE	Cytolysis in another organism →	-0.898	-0.558	.008	.008	2	10
BONE	Dentinogenesis →	-1.764	-0.804	.001	.008	2	9
BREAST	Regulation of potassium ion transmembrane transport →	-0.123	-1.445	<.001	<.001	3	8
BREAST	Response to vitamin K →	-1.406	-1.753	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,778 associations by consensus.

Glial cell fate commitment by FREM2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →