FREM2

Across TCGA cell cohorts, FREM2 mutation is significantly associated with the RNA expression of many other genes, with 1,262 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FREM2-associated genes across cancer lineages are ISOC1, LYG1, and SCD5. Each is linked with FREM2 in more than 2 cancer types. Because this analysis shows association rather than direction, both FREM2-to-partner and partner-to-FREM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ISOC1 grouped by FREM2-low versus FREM2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FREM2→partner) and Y-score (partner→FREM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ISOC1 →	+0.567	+1.936	.004	.004	3	3
LARGE_INTESTINE	LYG1 →	+0.823	+1.780	<.001	<.001	3	3
LARGE_INTESTINE	SCD5 →	+1.075	+1.483	.001	.002	3	3
LARGE_INTESTINE	TMEM237 →	+0.692	+2.222	.001	.001	3	3
LARGE_INTESTINE	PRKCQ →	+0.624	+1.693	.001	.008	3	3
BLOOD_Myeloma	SPATA22 →	+0.253	+3.906	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,262 associations by consensus.

ISOC1 by FREM2 expression — BLOOD_Leukemia

Explore this box plot interactively →