FREM1

Across TCGA patient cohorts, FREM1 RNA expression is significantly associated with the protein abundance of many other proteins, with 16,404 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible FREM1-associated proteins across cancer lineages are KANK2, PPP1R12B, and ADD3. Each is linked with FREM1 in more than 6 cancer types. Because this analysis shows association rather than direction, both FREM1-to-partner and partner-to-FREM1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FREM1 versus KANK2 in UCEC, with a Pearson correlation of 0.51.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (FREM1→partner) and Y-score (partner→FREM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KANK2 →	+0.634	+1.123	<.001	<.001	3	7
UCEC	PPP1R12B →	+0.898	+1.081	<.001	<.001	3	7
BRCA	ADD3 →	+0.507	+0.827	<.001	<.001	3	7
BRCA	HDGFL3 →	+0.774	+0.836	<.001	<.001	3	7
CCRCC	PRKG1 →	+0.645	+1.558	<.001	<.001	3	7
UCEC	MYLK →	+0.799	+0.974	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,404 associations by consensus.

FREM1 vs KANK2 — UCEC

Explore this scatter interactively →