FREM1

Across TCGA patient cohorts, FREM1 protein abundance is significantly associated with the RNA expression of many other genes, with 1,635 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible FREM1-associated genes across cancer lineages are PCDHB12, TDRD12, and ZNF250. Each is linked with FREM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FREM1-to-partner and partner-to-FREM1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FREM1 versus PCDHB12 in CCRCC, with a Pearson correlation of 0.31.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FREM1→partner) and Y-score (partner→FREM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PCDHB12 →	+0.680	+0.470	<.001	.003	3	2
UCEC	TDRD12 →	+0.890	+0.610	.002	.001	3	2
UCEC	ZNF250 →	-0.458	-0.372	.008	.002	3	2
UCEC	RHOT1P2 →	+1.434	+0.617	<.001	.002	3	2
UCEC	MAGI2-AS1 →	+0.781	+0.542	.006	<.001	3	2
GBM	CCNB1IP1 →	-0.609	-1.767	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,635 associations by consensus.

FREM1 vs PCDHB12 — CCRCC

Explore this scatter interactively →