FREM1

Across TCGA patient cohorts, FREM1 mutation is significantly associated with the RNA expression of many other genes, with 7,557 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FREM1-associated genes across cancer lineages are CHEK1, SLBP, and SAP30. Each is linked with FREM1 in more than 4 cancer types. Because this analysis shows association rather than direction, both FREM1-to-partner and partner-to-FREM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHEK1 grouped by FREM1-low versus FREM1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FREM1→partner) and Y-score (partner→FREM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CHEK1 →	+0.542	+2.169	.005	.009	3	5
STAD	SLBP →	+0.508	+2.733	.002	.003	3	5
UCEC	SAP30 →	+0.445	+1.540	<.001	<.001	3	5
STAD	MAD2L1 →	+0.897	+3.472	<.001	.002	3	5
UCEC	MELK →	+0.543	+2.126	<.001	<.001	3	5
UCEC	CENPN →	+0.591	+1.673	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,557 associations by consensus.

CHEK1 by FREM1 expression — LUAD

Explore this box plot interactively →