FREM1

Across TCGA patient cohorts, FREM1 mutation is significantly associated with the total protein of many other genes, with 80 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FREM1-associated genes across cancer lineages are Caspase-7-cleavedD198, ASNS, and XRCC1. Each is linked with FREM1 in more than 3 cancer types. Because this analysis shows association rather than direction, both FREM1-to-partner and partner-to-FREM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by FREM1-low versus FREM1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FREM1→partner) and Y-score (partner→FREM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.442	+3.717	<.001	<.001	3	4
COAD	ASNS →	+0.663	+3.008	<.001	<.001	3	4
LUAD	XRCC1 →	+0.138	+3.610	.017	.001	3	4
COAD	GAPDH →	+0.761	+3.321	<.001	.009	3	3
STAD	Annexin_VII →	-0.177	-3.584	.012	.002	3	3
STAD	TFRC →	+0.714	+3.169	.008	.018	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 80 associations by consensus.

Caspase-7-cleavedD198 by FREM1 expression — COAD

Explore this box plot interactively →