FREM1

Across TCGA cell cohorts, FREM1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,467 significant associations in total. BONE shows the largest number of these associations.

The most reproducible FREM1-associated GO terms across cancer lineages are COP9 signalosome assembly, Regulation of T-helper 1 cell cytokine production, and Positive regulation of T-helper 1 cell cytokine production. Each is linked with FREM1 in more than 5 cancer types. Because this analysis shows association rather than direction, both FREM1-to-partner and partner-to-FREM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COP9 signalosome assembly grouped by FREM1-low versus FREM1-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FREM1→partner) and Y-score (partner→FREM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	COP9 signalosome assembly →	+0.137	+1.392	<.001	.007	3	6
BONE	Regulation of T-helper 1 cell cytokine production →	-1.376	-3.136	<.001	<.001	3	6
BONE	Positive regulation of T-helper 1 cell cytokine production →	-1.376	-3.136	<.001	<.001	3	6
BONE	Regulation of transcription by RNA polymerase I →	+0.141	+2.583	<.001	<.001	3	6
BONE	Regulation of isotype switching to IgE isotypes →	-1.175	-2.865	<.001	<.001	3	6
BONE	Positive regulation of isotype switching to IgE isotypes →	-1.175	-2.865	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,467 associations by consensus.

COP9 signalosome assembly by FREM1 expression — BLOOD_Leukemia

Explore this box plot interactively →