FREM1

Across TCGA cell cohorts, FREM1 mutation is significantly associated with the RNA expression of many other genes, with 2,509 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FREM1-associated genes across cancer lineages are TRMU, UBXN4, and PHF5A. Each is linked with FREM1 in more than 2 cancer types. Because this analysis shows association rather than direction, both FREM1-to-partner and partner-to-FREM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRMU grouped by FREM1-low versus FREM1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FREM1→partner) and Y-score (partner→FREM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TRMU →	+0.511	+2.115	.001	.004	3	3
BLOOD_Leukemia	UBXN4 →	+0.509	+3.505	.005	.001	3	3
LARGE_INTESTINE	PHF5A →	+0.537	+2.458	<.001	<.001	3	3
LARGE_INTESTINE	HAUS8 →	+0.435	+1.949	.002	.002	3	3
LARGE_INTESTINE	SCLY →	+0.527	+3.257	.002	.002	3	3
SOFT_TISSUE	CRISP2 →	+0.106	+3.297	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,509 associations by consensus.

TRMU by FREM1 expression — LARGE_INTESTINE

Explore this box plot interactively →