FRAT2

Across TCGA cell cohorts, FRAT2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,787 significant associations in total. BONE shows the largest number of these associations.

The most reproducible FRAT2-associated GO terms across cancer lineages are Regulation of plasminogen activation, Regulation of coagulation, and Peptidyl-lysine oxidation. Each is linked with FRAT2 in more than 14 cancer types. Because this analysis shows association rather than direction, both FRAT2-to-partner and partner-to-FRAT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of plasminogen activation grouped by FRAT2-low versus FRAT2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FRAT2→partner) and Y-score (partner→FRAT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of plasminogen activation →	-0.342	-0.847	<.001	<.001	3	15
BONE	Regulation of coagulation →	-0.206	-0.796	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Peptidyl-lysine oxidation →	-1.557	-1.275	<.001	<.001	3	13
BONE	Regulation of protein maturation →	-0.204	-0.683	<.001	<.001	3	13
BREAST	Negative regulation of metallopeptidase activity →	-0.549	-1.044	<.001	<.001	3	13
LIVER	Urokinase plasminogen activator signaling pathway →	-1.241	-1.687	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,787 associations by consensus.

Regulation of plasminogen activation by FRAT2 expression — BONE

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