FRAT2

Across TCGA cell cohorts, FRAT2 mutation is significantly associated with the mutation status of many other genes, with 280 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FRAT2-associated genes across cancer lineages are CCDC159, TUBA1B, and RAB17. Each is linked with FRAT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FRAT2-to-partner and partner-to-FRAT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC159 grouped by FRAT2-low versus FRAT2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRAT2→partner) and Y-score (partner→FRAT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CCDC159 →	+4.523	+5.087	.006	.006	1	2
LARGE_INTESTINE	TUBA1B →	+4.523	+5.087	.006	.006	1	2
LARGE_INTESTINE	RAB17 →	+4.523	+5.087	.006	.006	1	2
LARGE_INTESTINE	PRRG3 →	+4.523	+5.087	.006	.006	1	2
LARGE_INTESTINE	PRR5L →	+4.523	+5.087	.006	.006	1	2
LARGE_INTESTINE	GULP1 →	+4.523	+5.087	.006	.006	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 280 associations by consensus.

CCDC159 by FRAT2 expression — LARGE_INTESTINE

Explore this box plot interactively →