FRAS1

Across TCGA patient cohorts, FRAS1 mutation is significantly associated with the RNA expression of many other genes, with 9,198 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FRAS1-associated genes across cancer lineages are PRC1, MYCT1, and KNL1. Each is linked with FRAS1 in more than 5 cancer types. Because this analysis shows association rather than direction, both FRAS1-to-partner and partner-to-FRAS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRC1 grouped by FRAS1-low versus FRAS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRAS1→partner) and Y-score (partner→FRAS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRC1 →	+0.464	+1.616	<.001	<.001	3	6
STAD	MYCT1 →	-0.642	-3.572	.001	.002	3	6
STAD	KNL1 →	+0.628	+2.906	.005	.001	3	6
STAD	KIF2C →	+0.716	+3.338	.003	.004	3	6
STAD	CCNA2 →	+0.878	+3.584	<.001	.002	3	6
STAD	E2F2 →	+0.955	+4.000	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,198 associations by consensus.

PRC1 by FRAS1 expression — UCEC

Explore this box plot interactively →