FRAS1

Across TCGA cell cohorts, FRAS1 mutation is significantly associated with the RNA expression of many other genes, with 2,067 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FRAS1-associated genes across cancer lineages are FASLG, IL10RB, and EPOP. Each is linked with FRAS1 in more than 3 cancer types. Because this analysis shows association rather than direction, both FRAS1-to-partner and partner-to-FRAS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASLG grouped by FRAS1-low versus FRAS1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRAS1→partner) and Y-score (partner→FRAS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	FASLG →	+0.125	+3.392	<.001	.003	3	3
BREAST	IL10RB →	-0.655	-3.307	.006	.002	3	3
LUNG_NSCLC_LUAD	EPOP →	+0.897	+3.226	<.001	.004	2	4
BREAST	TCF3 →	+0.637	+2.372	.009	.009	3	3
LUNG_NSCLC_LUAD	PDCD2L →	+0.447	+2.621	.008	.003	3	3
LARGE_INTESTINE	TOP3B →	+0.571	+3.169	.006	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,067 associations by consensus.

FASLG by FRAS1 expression — OVARY

Explore this box plot interactively →