FPR1

Across TCGA patient cohorts, FPR1 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FPR1-associated genes across cancer lineages are STAT3_pY705, ATM, and eEF2. Each is linked with FPR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FPR1-to-partner and partner-to-FPR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by FPR1-low versus FPR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FPR1→partner) and Y-score (partner→FPR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.480	-3.459	<.001	.005	3	2
UCEC	ATM →	-0.738	-2.321	<.001	.034	3	2
SKCM	eEF2 →	+0.245	+2.115	.047	.017	3	2
SKCM	EGFR →	-0.147	-2.700	.016	.005	3	2
SKCM	Paxillin →	+0.354	+3.000	.021	.034	3	2
SKCM	4E-BP1_pT70 →	+0.160	+2.186	.017	.032	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

STAT3_pY705 by FPR1 expression — UCEC

Explore this box plot interactively →