FPGT

Across TCGA pan-cancer cohorts, FPGT mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated FPGT data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher FPGT mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated FPGT expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

PDAC, LUAD, and GBM are the cancer types where FPGT mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	IV	0.455	0.836	.024	6	view →
LUAD	DFS	Median	All	0.448	0.826	.013	2	view →
GBM	OS	Quartile	All	0.972	0.721	.026	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

FPGT–PDAC (OS)

Open the PDAC breakdown →