FPGT

Across TCGA pan-cancer cohorts, FPGT mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of FPGT’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where FPGT mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types FPGT is over-expressed in tumor, although a few such as LSCC and COAD show the opposite, repressed pattern.

LSCC, COAD, and CCRCC are the cancer types where FPGT tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FPGT mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Female	All	−0.230	<.001	9	view →
COAD	All	III,IV	−0.182	<.001	9	view →
CCRCC	Male	III,IV	+0.142	.007	3	view →
HNSC	All	All	−0.074	.042	2	view →
PDAC	All	III,IV	+0.297	.028	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

FPGT–LSCC

Open the LSCC breakdown →