FPGT

Across TCGA patient cohorts, FPGT mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FPGT-associated genes across cancer lineages are FOXO3a_pS318_S321, Notch1, and p38-MAPK_pT180_Y182. Each is linked with FPGT in more than 1 cancer types. Because this analysis shows association rather than direction, both FPGT-to-partner and partner-to-FPGT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by FPGT-low versus FPGT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FPGT→partner) and Y-score (partner→FPGT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.164	-3.321	.012	.010	3	1
UCEC	Notch1 →	+0.187	+3.321	.011	.010	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.468	-3.000	.047	.036	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.758	+3.321	.004	.010	1	1
UCEC	MEK1 →	+0.582	+3.321	.002	.010	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

FOXO3a_pS318_S321 by FPGT expression — UCEC

Explore this box plot interactively →