FPGS

Across TCGA patient cohorts, FPGS mutation is significantly associated with the RNA expression of many other genes, with 428 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FPGS-associated genes across cancer lineages are LINC00351, NOCT, and CHAF1A. Each is linked with FPGS in more than 1 cancer types. Because this analysis shows association rather than direction, both FPGS-to-partner and partner-to-FPGS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC00351 grouped by FPGS-low versus FPGS-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FPGS→partner) and Y-score (partner→FPGS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	LINC00351 →	+0.162	+5.201	<.001	.007	3	2
UCEC	NOCT →	+0.652	+2.233	.001	.006	3	2
UCEC	CHAF1A →	+0.551	+2.243	.006	.006	3	2
UCEC	CXCR6 →	+0.832	+2.917	<.001	.001	3	2
UCEC	TXLNA →	+0.342	+2.732	.008	.003	3	2
LGG	MIR582 →	+0.663	+6.787	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 428 associations by consensus.

LINC00351 by FPGS expression — CESC

Explore this box plot interactively →