FPGS

Across TCGA patient cohorts, FPGS mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FPGS-associated genes across cancer lineages are p62 Lck ligand, p70-S6K_pT389, and Rab11. Each is linked with FPGS in more than 1 cancer types. Because this analysis shows association rather than direction, both FPGS-to-partner and partner-to-FPGS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by FPGS-low versus FPGS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FPGS→partner) and Y-score (partner→FPGS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.324	+3.331	.032	.005	3	1
UCEC	p70-S6K_pT389 →	-0.178	-2.312	.045	.034	3	1
UCEC	Rab11 →	-0.137	-3.169	.043	.018	3	1
UCEC	Annexin-1 →	+0.821	+3.700	<.001	.001	3	1
UCEC	Shc_pY317 →	-0.166	-2.584	.019	.011	3	1
UCEC	VHL →	-0.908	-3.321	.004	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

p62 Lck ligand by FPGS expression — UCEC

Explore this box plot interactively →